LACE: Inference of cancer evolution models from longitudinal single-cell sequencing data

Daniele Ramazzotti,Fabrizio Angaroni,Davide Maspero,Gianluca Ascolani,Isabella Castiglioni,Rocco Piazza,Marco Antoniotti,Alex Graudenzi

Journal of Computational Science（2022）

引用 12|浏览8

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摘要

The rise of longitudinal single-cell sequencing experiments on patient-derived cell cultures, xenografts and organoids is opening new opportunities to track cancer evolution, assess the efficacy of therapies and identify resistant subclones.

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关键词

Cancer evolution,Single-cell sequencing,Longitudinal data,Phylogenomics

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