Evaluation of a multiple microemulsion from Trichilia catigua extract and the percutaneous penetration through skin by Phase-Resolved photoacoustic spectroscopy

Audrey Alesandra Stinghen Garcia Lonni,Débora Dahmer, Isabela Almeida Pacheco da Costa,Maria Cristina DiCiaula,Mariane Roberta Ritter,Marcos Luciano Bruschi,Francine Baesso Guimarães,Antonio Carlos Bento,Jurandir Hillmann Rohling,Eneri Vieira de Souza Leite Mello,Maria Raquel Marçal Natali,Mauro Luciano Baesso,João Carlos Palazzo de Mello

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2022）

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摘要

•A micro W/O/W multiple emulsion with encapsulated Trichilia catigua was developed.•The microemulsion is safe of adverse effects by toxicity and histological analysis.•Phase Resolved Photoacoustic method provided microemulsion diffusion into the skin.•Absorption of extract was detected at the dermis.•The microemulsion encapsulated natural antioxidant has the potential for skincare use.

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关键词

Encapsulated natural antioxidants,Multiple microemulsion,Histological and toxicological studies,Trichilia catigua,Percutaneous penetration,Phase-resolved photoacoustic spectroscopy

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