PML Body Component Sp100A Restricts Wild-Type Herpes Simplex Virus 1 Infection

Yilei Ma,Jingjing Li,Hongchang Dong,Zhaoxin Yang,Lingyue Zhou,Pei Xu

Journal of virology（2022）

引用 3|浏览18

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摘要

Previous studies show that the PML body component Sp100 protein is immediately targeted by ICP0 of HSV-1 in the nucleus during productive infection. Therefore, extensive studies investigating the interplay of Sp100 isoforms with HSV-1 were conducted using a mutant virus lacking ICP0 or in the absence of infection.

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关键词

PML,Sp100A,cytosolic Sp100,HSV-1,EVs,extracellular vesicle,subcellular localization

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