Urine surface-enhanced Raman spectroscopy combined with SVM algorithm for rapid diagnosis of liver cirrhosis and hepatocellular carcinoma

Wubulitalifu Dawuti,Xiangxiang Zheng,Hui Liu,Hui Zhao,Jingrui Dou,Li Sun,Jin Chu,Renyong Lin,Guodong Lü

Photodiagnosis and Photodynamic Therapy（2022）

引用 16|浏览3

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摘要

•The urine SERS spectra from liver cirrhosis, hepatocellular carcinoma (HCC) and healthy person is different.•The urine SERS spectra combined with SVM algorithm has great potential to be developed for the diagnosis of HCC and liver cirrhosis.•The diagnostic sensitivity for HCC of urine SERS technology combined with SVM algorithm is better than the one of serum AFP method, which was used widely in clinical diagnosis for HCC.

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关键词

Surface-enhanced Raman spectroscopy (SERS),Urine,Liver cirrhosis,Hepatocellular carcinoma (HCC),Diagnosis,Alpha fetoprotein (AFP),Support vector machine (SVM)

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