Effects of prenatal opioid and alcohol exposures on immune and serotonin factors in human placenta

Sharon L. Ruyak,Shahani Noor,Jared DiDomenico,Melody S. Sun,Annette K. Fernandez Oropeza,Dominique E. Rodriguez,Lidia Enriquez Marquez,Erin D. Milligan,Ludmila N. Bakhireva

Experimental Neurology（2022）

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摘要

•PAE may inhibit the protective mechanism of SERT while simultaneously promoting TPH1 protein expression in human placenta.•Prenatal opioid and alcohol exposures may affect expression of cytokines in human placenta.•Prenatal opioid or alcohol exposure may perturb the dynamic interaction between the placental immune and serotonin system.

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关键词

Medications for opioid use disorder (MOUD),Prenatal alcohol exposure (PAE),Placenta,Immune,Cytokines,Serotonin

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