谷歌浏览器插件
订阅小程序
在清言上使用

Promyelocytic leukemia protein is a restriction factor for Junin virus independently of Z matrix protein

Biochemical and Biophysical Research Communications(2022)

引用 0|浏览28
暂无评分
摘要
The New World (NW) mammarenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the mechanism/s behind PML-mediated antiviral effect may be diverse and are a matter of debate. Previous studies have reported a nuclear to cytoplasm translocation of PML during the murine Old World mammarenavirus lymphocytic choriomeningitis virus (LCMV) infection. This translocation was found to be mediated by the viral Z protein. Here, we show that PML restricts JUNV infection in human A549 cells. However, in contrast to LCVM, JUNV infection enhances PML expression and PML is not translocated to the cytoplasm neither it colocalizes with JUNV Z protein. Our study demonstrates that a NW mammarenavirus as JUNV interacts differently with the antiviral protein PML than LCMV. (c) 2022 Elsevier Inc. All rights reserved.
更多
查看译文
关键词
Mammarenavirus,Junin virus,Promyelocytic leukemia protein,Restriction factor
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要