Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach

Davorka Breljak,Vedran Micek,Marko Gerić,Goran Gajski,Saša Kralik Oguić,Dubravka Rašić,Dean Karaica,Ivana Vrhovac Madunić,Marija Ljubojević,Tatjana Orct,Jasna Jurasović,Ivana Novak Jovanović,Maja Peraica,Lucia Nanić,Ivica Rubelj,Ivan Sabolić

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2022）

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摘要

•Antioxidants melatonin and resveratrol may act as anti-aging compounds.•Male and female rats drank melatonin or resveratrol solutions for 9 or 21 months.•Body mass, and various parameters in blood cells and plasma were determined.•With aging, body mass increased in both sexes, and plasma testosterone decreased in males.•The pattern of all parameters remanied unchaged in rats treated with antioxidants.

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关键词

GSH,MDA,MEL,ROS,RSV,RNS

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