Tuftsin ameliorates splenic inflammatory injury by promoting neuropilin-1 in severe acute pancreatitis

E Wen,Guang Xin,Shiyi Li,Yuman Dong,Yuda Zhu,Chengyu Wan,Xiuxian Yu,Zeliang Wei,Yilan Wang,Fan Li,Kun Zhang,Hai Niu,Wen Huang

Biochemical Pharmacology（2022）

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摘要

TN administration alleviates SAP-induced spleen inflammation injury by inhibiting macrophage M1 pro-inflammatory shifts and restoring mitochondrial damage as well as reducing ROS in an NRP1-dependent way.

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关键词

Severe acute pancreatitis,Spleen injury,Tuftsin,NRP1,Macrophage,Inflammation

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