Generation of an Induced Pluripotent Stem Cell (ipsc) Line from a Diabetic Patient with Glucagon Receptor (GCGR) P.w83x Mutation

Yang Liu,Yunbo Jia, Jing Lv,Dan Sun,Yalei Yin,Nan Liu,Benli Su,Guangwei Sun

Stem Cell Research（2022）

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Abstract

Induced pluripotent stem cell (iPSC) line, SJHi001-A, was generated from a diabetic patient carrying a heterozygous c.G248A mutation in GCGR gene that generated the p.W83X. The PBMCs from her father (no diabetes and no mutation site) were also prepared into iPSC (SJHi002-A) as a control. Both two cell lines had normal karyotype, expressed pluripotency markers and could differentiate into the three germ layers in vivo.

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Key words

Induced Pluripotent Stem Cells,Pluripotent Stem Cells

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