"Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE" Comment

The family of stromal interaction molecules (STIMs), comprising the homologs STIM1 and STIM2 with their different isoforms, has an intricate role in cellular calcium (Ca2+) homeostasis and signal transduction. While this is predominantly accomplished in concert with plasma membrane Orai proteins, STIM1 and STIM2 show essential functional differences, as was recently further elucidated by Ahmad et al. [1].