The correlation between genetic factors and freezing of gait in patients with Parkinson's disease

Branislava Radojević,Nataša T Dragašević-Mišković,Ana Marjanović,Marija Branković,Andona Milovanović,Igor Petrović,Marina Svetel,Ivan Jančić,Dejana Stanisavljević,Ognjen Milićević,Miroslav M Savić,Vladimir S Kostić

Parkinsonism & Related Disorders（2022）

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摘要

•Clinical-related risk factors to freezing of gait (FOG) in Parkinson's disease (PD) have been identified.•The influence of genetic variations on the FOG occurrence has been poorly studied thus far.•Genetic variants in dopamine-related genes might play a role in the FOG occurrence.•AA rs4680 COMT might contribute to FOG development among PD patients.•AGGAA and GGAAA haplotypes could act as protective and vulnerability factors for FOG occurrence.

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关键词

Parkinson's disease,Freezing of gait,Risk factors,Genetic polymorphisms,DRD2,COMT Val158Met

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