MDA5 expression is associated with TGF-β-induced fibrosis: potential mechanism of interstitial lung disease in anti-MDA5 dermatomyositis.

Ning Shen, Xiaopeng Zhou,Xuexiao Jin,Ci Lu,Xiuhua Hu, Yichi Zhang,Yu Jiang,Qin Xu, Xiayan Xu, Minghao Liu,Linrong Lu,Yongmei Han

Rheumatology (Oxford, England)（2022）

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摘要

Anti-MDA5 DM-ILD patients have significantly less lung fibrosis and elevated MDA5 expression. The upregulated expression of MDA5 has relations with the suppression of the pro-fibrotic function of fibroblasts via the TGF-β signalling pathway, which may partially explain the mechanism of the clinical phenomenon.

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关键词

DM,fibrosis,interstitial lung disease,melanoma differentiation-associated gene 5,transforming growth factor beta

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