Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. Sandra Martín-Peláez , Lluis Serra-Majem , Naomi Cano-Ibáñez , Miguel Ángel Martínez-González , Jordi Salas-Salvadó , Dolores Corella , Camille Lassale , Jose Alfredo Martínez , Ángel M Alonso-Gómez , Julia Wärnberg , Jesús Vioque , Dora Romaguera , José López-Miranda , Ramón Estruch , Francisco J Tinahones , José Lapetra , Fernando Fernández-Aranda , Aurora Bueno-Cavanillas , Josep A Tur , Vicente Martín , Xavier Pintó , Miguel Delgado-Rodríguez , Pilar Matía , Josep Vidal , Clotilde Vázquez , Lidia Daimiel , Emili Ros , Estefanía Toledo , Stephanie K Nishi , Jose V Sorli , Mireia Malcampo , M Ángeles Zulet , Anaí Moreno-Rodríguez , Raquel Cueto-Galán , Diego Vivancos-Aparicio , Antoni Colom , Antonio García-Ríos , Rosa Casas , M Rosa Bernal-López , Jose Manuel Santos-Lozano , Zenaida Vázquez , Carlos Gómez-Martínez , Carolina Ortega-Azorín , Jose Luís Del Val , Itziar Abete , Amaia Goikoetxea-Bahon , Elena Pascual , Nerea Becerra-Tomás , Juan J Chillarón , Almudena Sánchez-Villegas PloS one（2022）
摘要
Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
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