The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts.

Tiantian Qi,Ruihua Jing,Bo Ma,Conghui Hu,Chan Wen,Yongping Shao,Cheng Pei

Investigative ophthalmology & visual science（2022）

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摘要

Our findings revealed that reduced RNF157 expression promoted LEC apoptosis by upregulating p53 in cataracts, suggesting that the regulation of RNF157 expression may serve as a potential therapeutic strategy for cataracts.

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关键词

Cataract, RNF157, apoptosis, p53, ubiquitination

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