Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes

Dear Editor, Postovulatory aging would occur to impair the oocyte quality in a time-dependent manner if ovulated oocytes are not fertilized within the optimal tim-ing in the oviduct or in the dishes(Trapphoff et al.,2016),which might re-sult in the early pregnancy failure in vivo and adverse outcome of assisted repro-ductive technology(ART)in vitro(Nagy et al.,1993;Wilcox et al.,1998).How-ever,the effective approaches to pre-venting the postovulatory aging-induced oocyte deterioration are still underex-plored.