Advances in the clinical use of hydroxychloroquine levels

Purpose of review This review summarizes the recent literature exploring hydroxychloroquine levels and their relationship with disease activity and risk of toxicity. Recent findings There is no clear correlation between weight-based dosing of hydroxychloroquine and the resulting blood levels of the medication. Recent studies have shown that increased hydroxychloroquine levels are associated with lower lupus disease activity and likely also increased risk of medication toxicity. Mounting evidence supports use of hydroxychloroquine levels in clinical practice to document adherence and ensure safety.