FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression.

Sai Wang,Rilu Feng,Shan Shan Wang,Hui Liu,Chen Shao,Yujia Li,Frederik Link,Stefan Munker,Roman Liebe,Christoph Meyer,Elke Burgermeister,Matthias Ebert,Steven Dooley,Huiguo Ding,Honglei Weng

Gut（2023）

引用 4|浏览16

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摘要

FOXA2 replaces FXR to maintain MRP2 expression in ALF without sepsis. Ectopic FOXA2 expression to maintain MRP2 represents a potential strategy to prevent hyperbilirubinaemia in septic ALF.

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关键词

ACUTE LIVER FAILURE,CHOLESTASIS,SEPSIS

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