MHC class II inhibits the generation of IL-17A(+) V gamma 6 gamma delta T cells in the thymus at perinatal stage

Shinya Hatano,Keiichiro Mine,Naoto Noguchi,Mitsuru Matsumoto,Yoshihiro Baba,Yasunobu Yoshikai

EUROPEAN JOURNAL OF IMMUNOLOGY（2022）

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摘要

V gamma 6(+)gamma delta T cells develop in the thymus at the perinatal stage and are exclusive IL-17A producers among gamma delta T cells. The loss of MHC class II led to the expansion of IL-17A(+)V gamma 6(+)gamma delta T cells in the thymus. Thus, MHC class II in the thymus inhibits the generation of IL-17A(+)V gamma 6(+)gamma delta T cells.

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关键词

gamma delta T cells, V gamma 6, MHC class II, IL-17A, mTEC

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