Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway

Andrew Morris,Rosalie Hoyle,Piyusha P Pagare,Shadid Uz Zaman,Zhikun Ma,Jiong Li,Yan Zhang

Bioorganic Chemistry（2022）

引用 4|浏览13

暂无评分

摘要

•Wnt-signaling pathway is of interest for developing colorectal cancer therapeutics.•TCF4 plays an essential role in Wnt-signaling but was not a direct druggable target.•Chloro-naphthoquinones may target TCF4 directly to inhibit the Wnt-signaling pathway.•Chloro-naphthoquinone may act as a potential multi-targeting pharmacophore.

查看译文

关键词

Colorectal cancer,Wnt-signaling,Transcription,Cancer stem cell,Wnt target genes,Naphthoquinone

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要