α-Gal present on both glycolipids and glycoproteins contributes to immune response in meat-allergic patients

Neera Chakrapani,Jörg Fischer,Kyra Swiontek,Françoise Codreanu-Morel, Farah Hannachi,Martine Morisset,Clément Mugemana,Dmitry Bulaev,Simon Blank,Carsten Bindslev-Jensen,Tilo Biedermann,Markus Ollert,Christiane Hilger

Journal of Allergy and Clinical Immunology（2022）

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摘要

Both α-Gal-carrying glycoproteins and glycolipids are able to strongly activate patient basophils. In PK and beef, α-Gal epitopes seem to be less abundant on glycolipids than on glycoproteins, suggesting a major role of glycoproteins in delayed anaphylaxis upon consumption of these food sources.

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Glycolipids,α-Gal syndrome,red meat allergy,galactose-α-1,3-galactose,anaphylaxis,pork kidney,basophil activation,micelle formation,in vitro digestion

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