Exploring cyanobacterial diversity for sustainable biotechnology

This review discusses recent developments in the field of cyanobacterial genetic and metabolic diversity and how these can be harnessed to power a new dawn in green biotechnology. Cyanobacteria are an evolutionarily ancient and diverse group of microorganisms. Their genetic diversity has \nallowed them to occupy and play vital roles in a wide range of ecological niches, from desert soil crusts to tropical oceans. Owing to bioprospecting efforts and the development of new platform technologies enabling their study and manipulation, our knowledge of cyanobacterial metabolism is rapidly expanding. This review explores our current understanding of the genetic and metabolic features of cyanobacteria, from the more established cyanobacterial model strains to the newly isolated/described species, particularly the fast-growing, highly productive, and genetically amenable strains, as promising chassis for renewable biotechnology. It also discusses emerging technologies for their study and manipulation, enabling researchers to harness the astounding diversity of the cyanobacterial genomic and metabolic treasure trove towards the establishment of a sustainable bioeconomy.