Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell-mediated toxicity against glioblastoma.

Ruichong Ma,Margarida Rei,Isaac Woodhouse,Katherine Ferris,Sophie Kirschner,Anandhakumar Chandran,Uzi Gileadi,Ji-Li Chen,Mariana Pereira Pinho, Yoanna Ariosa-Morejon,Skirmantas Kriaucionis,Nicola Ternette,Hashem Koohy,Olaf Ansorge,Graham Ogg,Puneet Plaha,Vincenzo Cerundolo

Neuro-oncology（2022）

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摘要

Our work shows that DAC increases GBM immunogenicity and consequent susceptibility to T-cell responses in vitro. Our results support a potential use of DAC as a sensitizing agent for immunotherapy.

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关键词

decitabine,glioblastoma,immunotherapy,neoantigen,tumor immunology

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