Association of M2 Macrophages, Th2, and B Cells With Pathomechanism in Microscopic Polyangiitis Complicated by Interstitial Lung Disease.

Shogo Matsuda,Takuya Kotani,Hiroko Kuwabara,Takayasu Suzuka,Takao Kiboshi,Yumiko Wada,Takaaki Ishida,Youhei Fujiki,Hideyuki Shiba,Kenichiro Hata,Takeshi Shoda,Yoshinobu Hirose,Tohru Takeuchi

The Journal of rheumatology（2022）

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摘要

The activation of M2 macrophages, Th2 cells, and B cells plays a key role in the pathomechanism of MPA-ILD. Classification of MPA-ILD based on serum biomarker profile would be useful in predicting the disease activity and the complications of severe infection in MPA-ILD.

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关键词

biomarkers,cytokines,interstitial lung disease,microscopic polyangiitis,pulmonary histopathology

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