dl-isoprenaline hydrochloride solubility in four binary solvents at saturation: Thermodynamic analysis, Hansen solubility parameters and molecular simulation

•dl-isoprenaline hydrochloride solubility in four binary solvents were determined.•The miscibility of dl-isoprenaline hydrochloride in solvents was revealed by HSPs and MD simulation.•Experimental solubility was discussed and correlated by five models.•The thermodynamic properties of dl-isoprenaline hydrochloride were evaluated by van’t Hoff equation.