HIP1R and vimentin immunohistochemistry predict 1p/19q status in IDH-mutant glioma.

Marius Felix,Dennis Friedel,Ashok Kumar Jayavelu,Katharina Filipski,Annekathrin Reinhardt,Uwe Warnken,Damian Stichel,Daniel Schrimpf,Andrey Korshunov, Yueting Wang,Tobias Kessler,Nima Etminan,Andreas Unterberg,Christel Herold-Mende,Laura Heikaus,Felix Sahm,Wolfgang Wick,Patrick N Harter,Andreas von Deimling,David E Reuss

Neuro-oncology（2022）

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摘要

We demonstrate that immunohistochemistry for HIP1R, vimentin, and ATRX predict 1p/19q status with 100% specificity and 95% sensitivity and therefore, constitutes a simple and inexpensive approach to the classification of IDH-mutant glioma.

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关键词

1p/19q,ATRX,HIP1R,IDH,Vimentin,proteomics

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