Enhanced plasma persistence of ceftriaxone following single intramuscular injection with prior oral dosing of a mammary protective commercial herbal drug as complementary therapy

•Fibrosin®, a commercial herbal drug is used for a long time as supportive therapy in mastitis.•Fibrosin® was given orally 1 h prior to intramuscular ceftriaxone to study disposition kinetics.•Ceftriaxone showed a reabsorption half-life (t½Ka′) of 0.18±0.003 h in presence of Fibrosin®.•The reabsorption rate constant of ceftriaxone (3.86±0.10 h−1) suggested rapid intestinal reabsorption.