Probing the Statistical Structure of Memory Representation in Normal and Amnestic Mice

Understanding how a brain represents information is a fundamental process that informs potential treatments for a variety of neurodegenerative and psychiatric conditions, including major depressive disorder and PTSD. Here, we used a 1-photon calcium imaging and detailed behavioral analysis to compare how contextual fear memories are represented in dorsal hippocampus of normal and "forgetful” mice.