IL-28B reprograms tumor-associated macrophages to promote anti-tumor effects in colon cancer

Dalei Cheng,Haiyan Wang,Hongyan Cheng,Hui Zhang,Guanjun Dong,Fenglian Yan,Zhaochen Ning,Changying Wang,Li Wei,Xin Zhang,Junfeng Zhang,Huabao Xiong

International Immunopharmacology（2022）

引用 2|浏览6

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摘要

•IL-28B inhibits colon cancer growth in a mouse colon cancer model.•IL-28B does not promote MC38 tumor cell apoptosis in vitro.•IL-28B inhibits M2 macrophages in the tumor microenvironment.•IL-28B truncates M2 macrophage differentiation.•IL-28B inhibits the STAT3 and JNK signaling pathways.

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关键词

IL-28B,Colorectal cancer,M2 macrophage,Cancer immunotherapy,Anti-tumor

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