Predictive Ability of Serum Advanced Glycation End Products at 11 to 13 Weeks of Gestation for Early-Onset Preeclampsia

Minako Goto,Sho-ichi Yamagishi,Takanori Matsui,Keiko Koide,Hiroko Takita,Mayumi Tokunaka,Akihiko Sekizawa

AJOG global reports（2022）

Cited 2|Views7

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Abstract

•AGEs at 11 to 13 weeks of gestation were significantly higher in patients with EOPE.•AUROC curve for the AGE-to-PlGF ratio was significantly higher than that of AGEs.•The AGE-to-PlGF ratio and MAP detected EOPE with 100% accuracy (FPR of 10%).

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Key words

advanced glycation end product,biomarker,early-onset preeclampsia,first-trimester screening,mean arterial pressure,placental growth factor,uterine artery pulsatility index

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