Protocol of a systematic review with meta-analysis: The effects of physical exercise/activity on body composition of individuals with cardiometabolic multimorbidity v1

Multimorbidity can be defined as the combination of 2 or more chronic diseases and affects an increasing number of individuals worldwide. Among the various chronic conditions, cardiometabolic diseases stand out as the main causes of death in the world and their management has been increasingly discussed, from the need for specialized clinics, to the creation of a new medical specialty, to the need for effective interventions. The regular practice of physical activity is an important tool recommended to treat and prevent the worsening of the health status of patients with cardiometabolic diseases. In addition, comprehensive monitoring of cardiometabolic parameters such as body composition is necessary to understand the individual's health status, as well as verify the effectiveness of drug treatments and interventions. It is known that exercise has a beneficial effect on these components, but there is still little evidence exploring its effect on the coexistence of diseases and treatments for populations with cardiometabolic multimorbidity. Thus, the objective of the systematic review is to explore the effects of physical exercise and physical activity on body composition in individuals with cardiometabolic multimorbidity. For this, we will carry out a systematic review with meta-analysis in digital databases (PUBMED, EMBASE, CINAHL, Sportsdiscuss and Prospero).