Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs

Kun Zhao,Xiaoxiang Sun,Caihong Zheng,Mengting Wang,Zhu Xu,Mingzhu Wang,Jiayu Chen,Mingyue Guo,Rongrong Le,Li Wu,Yibin Wang,Xiaochen Kou,Yanhong Zhao,Jiqing Yin,Hong Wang,Zhiyong Mao,Shaorong Gao,Shuai Gao

Science Bulletin（2022）

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摘要

Differentiated somatic cells can be reprogrammed into induced pluripotent stem cells(iPSCs)by overexpression of specific tran-scription factors,such as Yamanaka factors(Oct4,Sox2,Klf4,and c-Myc,abbreviated as OSKM).iPSCs hold great promise for broad clinical application due to their extraordinary ability to self-renew and differentiate into different functional cell types.

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