Optimizing Nanoencapsulation of Heracleum Lasiopetalum by Response Surface Methodology

This study was carried out to optimize formulation for HeracleumLasiopetalum (golpar) extract nanoencapsulation by response surfacemethodology (RSM). The primary emulsion was fabricated by (5-10 %)golpar extract (GE), (40-35 %) emulsifier span 80 (EM), and (50-60 %)sunflower oil (SO). The coating materials of nanoencapsulation were thecomposition of Lepidium sativum seed gum (LSG) and whey proteinconcentrate (WPC) at different ratios (1:0, 1:1, and 0:1). The yield ofnanoencapsulation of golpar extract, particle size, and zeta potentialwas investigated as responses of RSM. The optimal formulation fornanoencapsulation of golpar extract were SO: 50.46%, GE 9.52%, and EM:36.30% in LSG, SO: 57.07%, GE: 7.12%, and EM: 30.85% in LSG:WPC, andSO: 54.98%, GE: 9.05%, and EM: 39.87% in WPC coating. In conclusion,the nanoencapsulation of golpar extract prepared with the optimizedformulation by RSM ensures the gradual release and sedimentation duringstorage with nanometric size and high yield of encapsulation. Thenanocapsules of golpar extract can be used as a natural antioxidant infood systems.