Acute Myeloid Leukemia Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

Husheng Ding,Jennifer S. McDonald,Seongseok Yun,Paula A. Schneider,Kevin L. Peterson,Karen S. Flatten,David A. Loegering,Ann L. Oberg,Shaun M. Riska,Shengbing Huang,Frank A. Sinicrope,Alex A. Adjei,Judith E. Karp,X. Wei Meng,Scott H. Kaufmann

semanticscholar（2013）

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摘要

1Division of Oncology Research, Department of Oncology; 2Department of Molecular Pharmacology and Experimental Therapeutics; 3Division of Biomedical Statistics, Department of Health Sciences Research; and 4Division of Gastroenterology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN; 5Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY; and 6Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA

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