CRP , and albumin predict cognitive decline in Parkinson ’ s Disease 3 by 4

by 4 Junchao Shen BA1, Noor Amari BA1, Rebecca Zack BA1, R. Tyler Skrinak BA1, 5 Travis L. Unger BA1, Marijan Posavi PhD1, Thomas F. Tropea DO1, Sharon X. Xie2 PhD, 6 Vivianna M. Van Deerlin MD PhD3, Richard B. Dewey, Jr. MD4, Daniel Weintraub MD5,6, 7 John Q. Trojanowski MD PhD1, and Alice S. Chen-Plotkin MD1 8 9 Departments of 1Neurology, 2Biostatistics, Epidemiology and Informatics, 3Pathology and 10 Laboratory Medicine, 5Psychiatry, Perelman School of Medicine, University of Pennsylvania, 11 Philadelphia, PA. 4Department of Neurology, University of Texas Southwestern Medical Center, 12 Dallas, TX. 6Parkinson’s Disease Research, Education and Clinical Center (PADRECC), 13 Philadelphia Veterans Affairs Medical Center, Philadelphia, PA. 14 15 Corresponding Author: 16 Alice S. Chen-Plotkin MD 17 150 Johnson Pavilion 18 Philadelphia, PA 19104 19 215-573-7193 20 chenplot@pennmedicine.upenn.edu 21 22 Running head: Plasma biomarkers of PD cognitive decline 23 24 Character counts: Title 119 characters, Running head 36 characters 25 Word counts: Abstract 250 words, Introduction 443 words, Discussion 1331 words, Manuscript 26 4456 words 27 Figures and tables: 5 color figures, 2 tables 28