Imaging Protein Dynamics in Liquid Water

their natural rotation to the structural reconstructing its architecture in tomographic We test polymerase apoferritin. RNA polymerase the very flexible us dynamics. Apoferritin is cage-like spherical particle diameter of and 8nm It also 24-fold octahedral symmetry, it an for cryo-EM as the be multiplied by key for its selection. We that the to achieve sub-nanometer spatial resolutions of protein structures, by one and assessing different conformational states using Brownian Tomography combining proteins into one statistical conformational ensemble Brownian Particle Analysis The use of LTEM for investigation of proteins is not to reconstruction and structural to use we have imaged amyloid-β aggregation. Aβ is a small, peptide with 36-43 amino acids. Aβ accumulates into stages of microscopic amyloid fibres and that are found in brains by Alzheimer’s