Cerebrospinal fluid AΒ ₄₂ , total tau, and phosphorylated tau in the evaluation of Alzheimer’s dementia: Experience from a commercial reference laboratory

Sat Dev Batish,Farnoosh Haji‐Sheikhi,Amogh Kare,Vivekananda Datta,Marc Meservey,Jeff Radcliff

Alzheimer's & Dementia（2021）

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摘要

Aβ amyloid plaques and tau neurofibrillary tangles play an important role in Alzheimer’s disease (AD) pathophysiology, and the CSF biomarkers Aβ42, total tau (T‐tau), and phosphorylated tau181 (P‐tau) have been extensively used in diagnosing AD. Here we describe our experience with use of the Aβ42/T‐tau index (ATI) and P‐tau for classification of patients with suspected AD.

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Cerebrospinal fluid AΒ 42 , total tau, and phosphorylated tau in the evaluation of Alzheimer’s dementia: Experience from a commercial reference laboratory

Cerebrospinal fluid AΒ ₄₂ , total tau, and phosphorylated tau in the evaluation of Alzheimer’s dementia: Experience from a commercial reference laboratory