One-pot synthesis of benzo[c]chromene-6-ones via domino Suzuki-Miyaura cross-coupling followed by oxidative lactonization catalyzed by in situ generated palladium nanoparticles under aqueous-aerobic condition

Benzo[c]chromene-6-ones are the very significant class of lactones which constitute core structural subunits of various biologically and pharmaceutically active molecules and some important natural products.Importance of 6H-benzo[c]chromene-6-ones for its potential therapeutic and pharmaceutical properties, has attracted researchers over the decades towards the development of more convenient and straight forward route for the synthesis of these molecules. We have efficiently constructed a novel method for the one-pot synthesis of benzo[c]chromenones and their derivatives by palladium catalyzed domino Suzuki-Miyaura cross coupling and oxidative lactonization under aqueous-aerobic condition. We started our investigation by optimizing the reaction condition.