Prognostic factors in endometrial carcinoma – a single-center study

Summary Endometrial cancer (EC) is the fourth most common cancer in women in Croatia and the second most common gynecological malignancy with the trend of increasement in incidence. The aim of this single-centre study was to analyze ECs clinical and pathological characteristics and to assess the correlation between risk factors and the reccurence of the disease. We retrospectively reviewed medical records of 174 women that were diagnosed with endometrial cancer between January 2011 and May 2015. Among the women that were diagnosed ECs in the patohistologic specimen, histologic subtype, grade, cancer stage, depth of myometrial tumor invasion, presence of lymph-vascular space involvement (LVSI), lower uterine segment or surface cervical glandular involvement were documented. In addition, women’s age, BMI, number of successful deliveries and comorbidities (diabetes mellitus and hypertension) were obtained and incorporated in the statistical analysis. We demonstrated a strong corellation between higher tumor grade, deeper myometrial invasion, presence of lymphovascular space invasion and disease reccurence in our cohort. Due to rapid increasement in incidence, further education, increasement of public awareness, measures for prevention, diagnostic procedures and advances in therapy are imperative to decrease the overall morbidity and mortality rate.