P464. Magnetoencephalographic Examination of Neural Synchronization in Gamma Frequency Ranges in Pediatric Subjects With Obsessive Compulsive Disorder in Response to an Auditory Chirp Stimulus

Obsessive compulsive disorder (OCD) is a common psychiatric disorder that may be related to an impaired inhibitory process. Reduced local circuit inhibition leading to an inability to synchronize neural responses to sensory input is hypothesized to lead to increased gamma activity. Oscillating auditory stimuli have previously been used to demonstrate a reduced ability of subjects with other developmental disorders (e.g., Autism Spectrum Disorder) to synchronize neural activity at higher gamma frequencies. Because there may be a common developmental phenotype amongst these disorders, we hypothesized that subjects with OCD may exhibit similar deficits in neural synchronization.