A Screening of Probiotics for Renal Protection in the Cisplatin-Induced Acute Kidney Injury Animal Model

Nephrotoxicity is a common side effect of using the anti-cancer drug, cisplatin. In recent years, many studies have been devoted to reduce the side effects of cisplatin chemotherapy, especially the protection of the kidneys. Since the mechanism of cisplatin on kidney damage is complicate, the materials with specific mechanism for renal protection had their limitations. The mechanisms by which probiotics are beneficial to humans have many aspects, such as promoting intestinal health and improving immunity. In recent years, there have also been studies on the relationship of probiotics in the gut-kidney axis. Since different probiotic strains have different effects, it is necessary to screen the strains with kidney protection. In this experiment, lactic acid bacteria were isolated from edible animal or plant materials, and then were applied to the ICR mice with acute kidney injury induced by a single dose of cisplatin. It was compared by feeding different strains 10 days before whether protecting the kidneys after 4 days of induction or not. Among the 5 isolated strains, Lactobacillus rhamnosus GKLC1 could slow down the increase in blood urea nitrogen and creatinine caused by cisplatin. In the pathological analysis of kidney tissue, compared with other groups, the less tissue necrosis was also observed in the GKLC1 group. The results in this screening test revealed that L. rhamnosus GKLC1 has the potential effects for the renal protection.