Protein expression by immunohistochemistry is associated with CCNE1 and BRD4 gene amplification

Shariska Petersen, Shivani Golem,Parmida Shahiri,Andrew Wilson, Lori Spoozak,Andrea Jewell,Dineo Khabele

Gynecologic Oncology（2022）

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摘要

In high grade serous ovarian cancer (HGSOC), co-amplification of CCNE1 and bromodomain and extraterminal 4 (BRD4) genes is associated with poor overall survival. Our objective was to determine if protein expression by immunohistochemistry can be used as a surrogate marker for CCNE1 and BRD4 amplification measured by fluorescent in situ hybridization (FISH).

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Protein expression by immunohistochemistry is associated with CCNE1 and BRD4 gene amplification

Protein expression by immunohistochemistry is associated with CCNE1 and BRD4 gene amplification