Dissociation of lipid transfer activities of MTTP 1 2 3 A missense mutation dissociates triglyceride and phospholipid transfer activities 4 in zebrafish and human microsomal triglyceride transfer protein 5 6 7

Running Title: Dissociation of lipid transfer activities of MTTP 1 2 3 A missense mutation dissociates triglyceride and phospholipid transfer activities 4 in zebrafish and human microsomal triglyceride transfer protein 5 6 7 Meredith H. Wilson, Sujith Rajan, Aidan Danoff, Richard J. White, Monica R. Hensley, 8 Vanessa H. Quinlivan, James H. Thierer, Elisabeth M. Busch-Nentwich, 9 M. Mahmood Hussain, Steven A. Farber 10 11 1 Carnegie Institution for Science Department of Embryology, Baltimore, MD 21218 12 2 New York University Winthrop Hospital, Mineola, NY11501 13 3 Johns Hopkins University Department of Biology, Baltimore, MD 21218 14 4 Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, 15 CB101SA, UK 16 5 Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK 17 18 Footnote: 19 *Corresponding Author: Steven A. Farber farber@carnegiescience.edu 20 M. Mahmood Hussain Mahmood.Hussain@nyulangone.org 21 22 23 24 SUMMARY 25 26 Microsomal triglyceride transfer protein (MTP) transfers triglycerides and phospholipids and is 27