Outcomes with culture-directed antibiotics following microvascular free tissue reconstruction for osteonecrosis of the jaw

Riddhima Agarwal,Taylor E Freeman,Michael M Li,Akash N Naik,Ramez W Philips,Stephen Y Kang,Enver Ozer,Amit Agrawal,Ricardo L Carrau,James W Rocco,Matthew O Old,Nolan B Seim

Oral Oncology（2022）

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摘要

•Osteoradionecrosis and bisphosphonate-related osteonecrosis of the jaw pose difficult treatment scenarios with higher complication rates.•Long-term IV antibiotics directed by residual mandible cultures may decrease complication rates in free flap reconstruction of osteoradionecrosis.•Free tissue transfer of non-irradiated, well-vascularized free tissue may improve tissue perfusion to the irradiated region as well as antibiotic delivery.•Long-term IV antibiotics may provide benefit by treating Actinomyces.

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关键词

Head and neck cancer,Oral cancer,Osteoradionecrosis,Osteonecrosis,Microvascular free tissue transfer,Post-operative antibiotic therapy

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