Pivotal role of adipocyte-Na/K-ATPase Signaling in the pathogenesis of Experimental Uremic Cardiomyopathy by fat transplantation.

The study demonstrates that, the inhibition of adipocyte-NKA signaling in uremic cardiomyopathy could modulate the adipocyte redox state that resulted in the manipulation of systemic inflammatory milieu and associated pathophysiological mechanisms, which can be used as a clinical target for therapeutic intervention of uremic cardiomyopathy.