The Magnitude of Long-Term Facilitation is Influenced by Modifications to Mild Intermittent Hypoxia Protocols in Participants with OSA.

Our results showed that LTF of minute ventilation can be initiated using two different protocols that varied in regard to episode duration and the degree to which P CO is maintained above baseline. We also showed that increases in episode duration and sustained P CO results in a greater magnitude of LTF on a given day. Moreover, these modifications appear to enhance the magnitude of LTF following repeated daily exposure.