Peripheral Chemoreflex Sensitivity is Augmented in Human Type 2 Diabetes.

Individuals with type 2 diabetes exhibit exaggerated peripheral chemoreflex sensitivity which is associated with disease severity (i.e., HbA1c). In contrast, the contribution of the peripheral chemoreceptors to basal cardiovascular function in type 2 diabetes does not differ from non-diabetic controls. Results advance our understanding of the pathogenesis of type 2 diabetes and related complications.