Loss of Pkm2 Alters Myocardial Metabolism and Increases Oxidative Stress After Infarction

Katie C. Lee,Allison L. Williams,Ralph V. Shohet

CIRCULATION RESEARCH（2022）

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摘要

RNA-seq analysis of Pkm2 KO hearts demonstrated that loss of Pkm2 altered gene expression of metabolic and mitochondrial enzymes. Pkm2 KO hearts also showed increased abundance of pro-apoptotic markers which may be a result of increased oxidative stress.

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