Metabolic Alterations in Aorta Induces Brain Cholesterolemia, Memory Loss and Cognitive Dysfunction in Diabetic Mice.

Chandrakala Aluganti Narasimhulu,Dinender Singla

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

In conclusion, our data suggest that hyperlipidemia induces apoptosis, that leads to neuronal cell death, memory-loss, and cognitive dysfunction, which furthers Alzheimer's in diabetic ApoE and PON1 DKO mice. Further therapeutic approaches require to be developed to target hyperlipidemia in diabetic brains.

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关键词

cognitive dysfunction,hyperglycemia,hyperlipidemia,inflammation

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