Assessment of Hindlimb Myopathy and Mitochondrial Bioenergetics in a Unique Mouse Model of Access‐related Hand Dysfunction
The FASEB journal(2022)
摘要
Iliac AVF creation resulted in central and peripheral hemodynamic alterations, impaired hindlimb neuromotor function, mitochondrial dysfunction, and morphological deformation. Taken together, we identify several key pathophysiological aspects of ARHD in a pre-clinical model providing a platform to facilitate mechanistic and therapeutic studies aimed to reduce ARHD prevalence in CKD patients.
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