Utilization of Zebrafish Larvae to Monitor Gastric Motility in Diabetes Mellitus: Targeting GLP-1 and GIP Receptors.

Chung Man,Jessica Hui,Peng Du,Yuen Hang Julia Liu,Zengbing Lu,Dexuan Cui, Bing Jiang,Man Piu Ngan,Shuk Han Ng,Lingqing Yang,Aleena Khalid,Luping Liu,John A. Rudd

The FASEB journal（2022）

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摘要

Three DM models and an obesity model using zebrafish larvae were successfully established. Advanced imaging and processing techniques revealed intricate subtypes of dysmotility in DM and obesity. Exendin-4 and tirzepatide at high doses reduced motility in normal fish which may be consistent with their clinical side effect profile.

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